Search results for "3D models"
showing 10 items of 11 documents
Preclinical models in oncological pharmacology: limits and advantages
2021
A wide range of experimental tumor models, each with distinct advantages and disadvantages, is nowadays available. Due to the inherent differences in their complexity and functionality, the choice of the model is usually dependent on the application. Thus, to advance specific knowledge, one has to choose and use appropriate models, which complexity is largely dependent on the hypotheses to test, that is on the objectives. Whatever the model chosen, the complexity of cancer is such that none of them will be able to fully represent it. In vitro tumor models have provided important tools for cancer research and still serve as low-cost screening platforms for drugs. The improved understanding o…
The Human Biodiversity in the Middle of the Mediterranean. Study of native and settlers populations on the Sicilian context
2020
[IT] Negli ultimi 200.000 anni, la specie umana si è diffusa in tutta la Terra, adattando la sua morfologia e fisiologia a un'ampia gamma di habitat. Lo scheletro umano ha quindi registrato i principali effetti ambientali e di conseguenza i reperti scheletrici assumono grande importanza nell'indagine dei processi evolutivi. Oggi le moderne tecniche di indagini quantitative delle principali caratteristiche morfologiche consentono di metterle in relazione con la variabilità genetica. La posizione geografica della Sicilia, l'isolamento e la sua lunga e dinamica storia di colonizzazione (diversi e numerosi contributi culturali e biologici) hanno creato un contesto peculiare che consente uno stu…
Within the symbolic world of the prehistoric hunters: A GIS-based and 3D model analysis of sites with complexes of linear incisions in western Sicily
2021
Abstract The prehistoric peopling of Sicily has left scattered traces of symbolic activities through well-known rock art expressions in caves and rock shelters located all around the island (among the most significant, the sites of Addaura, Racchio and Genovese). A peculiar phenomenon is the incision of linear signs, often grouped on the same rocky walls, hidden in fissures or placed at the entrance of the underground chambers of caves. In this report, we investigate a sample of these graphic expressions from a spatial and technical point of view. A GIS-based approach presents the territorial pattern providing insight, on a macroscale, into the intentional positioning of the sign complexes.…
Image-based 3D reconstruction using traditional and UAV datasets for analysis of road pavement distress
2018
Abstract On local and urban networks, the enduring issue of scarce resources for Maintenance, Rehabilitation, and Reconstruction strategies (MR&R) has led, in many cases, to using unadjusted or poor techniques for road pavement distress detection and analysis, yielding ineffective or even counterproductive results. Therefore, it is necessary to have tools that can carry out quick, reliable and low-cost assessment surveys. This paper aims at validating the use of innovative and low-cost technologies for road pavement analysis, assessing their potentialities for improving the automation and reliability of distress detection. A Structure from Motion (SfM) technique is analyzed at different alt…
Exploiting Low-Cost 3D Imagery for the Purposes of Detecting and Analyzing Pavement Distresses
2020
Road pavement conditions have significant impacts on safety, travel times, costs, and environmental effects. It is the responsibility of road agencies to ensure these conditions are kept in an acceptable state. To this end, agencies are tasked with implementing pavement management systems (PMSs) which effectively allocate resources towards maintenance and rehabilitation. These systems, however, require accurate data. Currently, most agencies rely on manual distress surveys and as a result, there is significant research into quick and low-cost pavement distress identification methods. Recent proposals have included the use of structure-from-motion techniques based on datasets from unmanned a…
TISSUE ENGINEERING FOR THE DEVELOPMENT OF THREE-DIMENSIONAL INVITRO MODELS OF HUMAN MUCOSAE
2014
Traditional two-dimensional (2D) cell cultures only partially reflect the morpho-molecular pattern of human cells in tissues, and they are also unable to fully mimic the complexity of the in vivo microenvironment. Cell development in in vivo systems differs significantly from classical 2D cell culture models, especially with regard to the morphology, growth kinetics, gene expression and the degree of differentiation. Tissue engineering allows the reproduction of tissues by cell seeding on biocompatible scaffolds, to form a homogenous ...
In assenza di intervento. Rappresentazioni digitali di restauri virtuali
2015
La simulazione della realtà attraverso le tecniche di rappresentazione digitale viene oggi in aiuto dei restauratori poiché consente loro di verificare l’impatto di un restauro ancor prima di intervenire. Ciò può contribuire a evitare interventi troppo invasivi e a contenere errate pratiche che, a volte, irrimediabilmente cancellano le tracce originali. Il saggio analizza alcune esperienze di ricerca sull’illuminazione nei modelli virtuali che sono emblematiche di un approccio possibile. Le ricostruzioni tridimensionali digitali analizzate forniscono non solo le informazioni spaziali e dimensionali ma anche gli aspetti cromatici e le caratteristiche di illuminazione di un’architettura. Lo s…
3D DATA INTEGRATION FOR WEB BASED OPEN SOURCE WebGL INTERACTIVE VISUALISATION
2022
Abstract. Recent advances in open-source geospatial technologies in WebGIS allowed the visualization of a 3D complex environment on the web, exploiting realistic Globe reproduction of the real territorial asset. At the same time, in the field of gaming technologies, the new possibilities offered by open-source WebGL JavaScript libraries allowed the creation of Virtual Reality navigation models on the web. The integration between 3D GIS globe navigation models and VR environment navigation is a solution that offers a further level of detail in web navigation, exploiting the capabilities of web browsers in the best way. This research further contributes to this field, showing a workflow to in…
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use…
2013
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, as well as hepatic metabolism, is controlled by a set of nuclear receptors (including PXR, CAR, HNF-4α, FXR, LXR, SHP, VDR and PPAR) and signaling pathways. When isolating liver cells, some pathways are activated, e.g., the RAS/MEK/ERK pathway, whereas others are silenced (e.g. HNF-4α), resulting in…
Characterization of a novel three-dimensional outgrowth model of human bronchial mucosa
2011
Recently it has been hypothesized that a reactivation of the epithelial-mesenchymal trophic unit (EMTU) of the respiratory mucosa, caused by extensive epithelial damage, may be responsible for the pathogenesis of asthma. However, most research on this subject so far has been limited by the unavailability of in vitro models correctly mimicking the three-dimensional architecture of the properly differentiated human bronchial mucosa. For this reason, we have developed a novel 3D outgrowth model, obtained from bronchial biopsies and composed of both human bronchial epithelial cells (goblet and columnar cells) and fibroblasts with their basement membrane. Here we present the preliminary data obt…